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Haptoglobin Typing

www.haptoglobintyping.org/

Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin (Hb) released ...

Haptoglobintyping.org

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Content: Starfield Technologies; Go Daddy Website Builder 7.0.5350
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Content: Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobulin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels. Conversely, in extravascular hemolysis the reticuloendothelial system, especially splenic monocytes, phagocytose the erythrocytes and hemoglobin is not released into circulation; serum haptoglobin levels are therefore normal. Haptoglobin Typing test will identify the Haptoglobin phenotype of a patient from blood plasma or serum (Hp 1-1, Hp 2-1, Hp 2-2) Research has shown that the Haptoglobin phenotype of a patient with Diabetes is directly associated with the risk of developing cardiovascular complications including death and renal failure.

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Country: United States
City: Scottsdale

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